In this episode of "Answers From the Lab," William Sukov, M.D., provides an overview of the MDM2 gene amplification assay — a test that looks for amplification of the MDM2 gene region on chromosome 12q. He reviews when this test should be ordered, how it compares to other test options, and how its results can affect patient care. https://mayocl.in/2H4rdBe | Mayo Clinic Laboratories
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William Sukov, M.D., reviews the MDM2 gene amplification assay. This test is important for diagnosing lipomas, and differentiating some malignancies from benign lesions or inflammatory lesions. The test also is useful for bone tumors, differentiating low-grade sarcomas from inflammatory or benign lesions. | Mayo Clinic Laboratories
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SOLVED: MDM2p53Active TetramersCell CycleFigure: MDM2 and p53 signaling in response to DNA damage controls cell cycle progressionThe p53 and MDM2 proteins are involved in the DNA damage response pathway (Figure 1). In the absence of DNA damage, MDM2 mediates the degradation of p53. In the presence of DNA damage, p53 is not broken down and forms active tetramers that stimulate the expression of genes that block cell cycle progression.Red blood cells are produced by the division and differentiatio
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