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1. A lump that’s new or growing. Anywhere — breast, neck, armpit, groin. Painless doesn’t mean harmless 2. Unexplained weight loss. Dropping pounds without trying is a major red flag 3. Bleeding that’s unusual. Blood in stool, urine, coughing blood, or abnormal vaginal bleeding 4. Change in bowel or bladder habits. New constipation, diarrhea, or urinary frequency that won’t go away 5. Pain that persists. Especially new, worsening, or unexplained pain lasting more than a few weeks