How did life come about? The answer to this question goes to the very heart of our existence on planet Earth. Did life simply arise from chemical reactions among organic compounds in a primordial soup ...
After encountering foreign antigen, B cells diversify their immunoglobulin genes by somatic hypermutation (SHM), gene conversion (GC) and class-switch recombination (CSR). SHM introduces mutations ...
Samples from the asteroid Ryugu collected by the Hayabusa2 mission contain nitrogenous organic compounds, including the nucleobase uracil, which is a part of RNA. Researchers have analyzed samples of ...
Cytolytic effects of CD8+ CTL clones specific for an HLA-A2 epitope from the 5T4 tumor antigen on tumor cells in vitro. Background: Fluoropyrimidines are the cornerstone of chemotherapeutic regimens ...
Phase I, Pharmacokinetic, and Pharmacodynamic Study of Intravenously Administered Ad5CMV-p53, an Adenoviral Vector Containing the Wild-Type p53 Gene, in Patients With Advanced Cancer UFT+LV achieved ...
Back in 2010, Japan’s space agency JAXA completed one of the biggest milestones in the history of space exploration: It collected samples from an asteroid and brought them back to Earth. A decade ...
In a previous phase 3 trial of adjuvant chemotherapy after resection of non–small-cell lung cancer, a combination of uracil and tegafur (often referred to as UFT) taken orally was shown to prolong ...
Protein p56 encoded by the Bacillus subtilis phage φ29 inhibits host uracil-DNA glycosylase (UDG) activity. In previous studies, we suggested that this inhibition is likely a defense mechanism ...
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