A fundamental method for generating a tertiary carbon stereocentre is to deliver a proton to a carbanion intermediate. However, enantioselective transfer of a proton presents unusual challenges — ...

Figure 1: CarB and ThnE are crotonase superfamily enzymes catalysing enolate alkylation. Here, we report studies on CMPS variants aimed at controlling the formation and/or reactivity of trisubstituted ...

The Thermo Scientific picoSpin 45 NMR spectrometer is a useful tool for teaching through the aldol condensation reaction. In a number of undergraduate organic teaching programs, probably the first ...

Ketones are in equilibrium with a form known as an enol. The name enol derives from the fact that enols are a combination of a carbonyl (C=O) containing group, such as an aldehyde or ketone and an ...