The cytochrome P450 enzymes form a vast superfamily of haem‐containing monooxygenases that catalyse the metabolism of a broad spectrum of endogenous substances and xenobiotics. Their dynamic catalytic ...

Cytochrome P450 (CYP450), is a family of hemoglobin-coupled monooxygenases. In mammals, CYP450 oxidizes steroids, fatty acids, and xenobiotics, playing an important role in the metabolism of various ...

Drugs are metabolized in the liver using several enzyme-catalyzed processes. These enzymes are collectively referred to as the hepatic microsomal enzyme system, and they are usually present in the ...

A family of nearly 3,000 artificial cytochrome P450 enzymes has been created by a California Institute of Technology team's efforts to recombine sections of three natural cytochrome P450s, a large ...

Isoflavonoids are distributed predominantly in leguminous plants and play critical roles in plant physiology. A cytochrome P450 (P450), 2-hydroxyisoflavanone synthase, is the key enzyme in their ...

To boost the statistical power to find Alzheimer’s genes, geneticists often use endophenotypes—measurable characteristics of the disease—in place of clinical diagnoses. Case in point: A genome-wide ...

Background: Clopidogrel is a prodrug requiring metabolism by cytochrome P450 3A (CYP3A) isoenzymes, including CYP3A5, in order to be active. It is controversial whether clopidogrel interacts with ...

Optibrium™, a developer of software for drug discovery, today announced the launch of version 6.5 of StarDrop™ that provides a complete platform for small molecule design, optimisation and data ...