To the untrained eye, the tiny spots in the tumor cell wouldn’t look like much. In fact, other scientists had noticed them in cancer before but had generally dismissed them as a mere curiosity. But to ...

Extrachromosomal circular DNA (ecDNA) represents a distinct genomic entity that exists independent of the primary chromosomal structure. In cancer, ecDNA is recognised as a potent driver of oncogene ...

A study of newly created databases of medulloblastoma has found that patients with tumors containing circular extrachromosomal DNA - loops of DNA found outside of regular chromosomes - are twice as ...

Like its viral cousins, a somewhat parasitic DNA sequence called a retrotransposon has been found borrowing the cell’s own machinery to achieve its goals. In a new work appearing online Wednesday in ...

Like its viral cousins, a somewhat parasitic DNA sequence called a retrotransposon has been found borrowing the cell's own machinery to achieve its goals. In a new work appearing online Wednesday in ...

Intergalactic Therapeutics has launched with $75 million in series A financing to develop a nonviral gene therapy. Most gene therapies rely on viral vectors to deliver DNA into the body, but ...

Figure 1. Design and synthesis of circAMO . (a) Synthesis of a single-molecule ring by rigid regulation of selectivity; (b) Schematic diagram of circAMO design; (c) Synthesis of circAMO; (d) ...