Nature

A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling

β-arrestins (β-arrestin1 and β-arrestin2) play central roles in the mechanisms regulating G protein-coupled receptor (GPCR) signalling and trafficking 1,2. The recruitment of β-arrestin to ...
JSTOR Daily

Heterodimerization of V1a and V2 Vasopressin Receptors Determines the Interaction with β-Arrestin and Their Trafficking Patterns

V1a vasopressin receptor (V1aR) and V2 vasopressin receptor (V2R) present distinct mechanisms of agonist-promoted trafficking. Although both receptors are endocytosed by way of β-arrestin-dependent ...
EurekAlert!

First evidence of a ‘nearly universal’ pharmacological chaperone for rare disease

A study published today in Nature Structural & Molecular Biology is the first time researchers have shown evidence that a single drug, already licensed for medical use, can stabilise nearly all ...
BioWorld

One-size-fits-(nearly)-all fix for V2R mutations

Genetic mutations are the primary cause of most rare diseases. Although each condition affects a small fraction of the population, the global impact is significant, with an estimated 300 million ...
technologynetworks

Drug Identified as First “Nearly Universal” Pharmacological Chaperone for Rare Disease

A study published today in Nature Structural & Molecular Biology is the first time researchers have shown evidence that a single drug, already licensed for medical use, can stabilise nearly all ...